Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive genetic mutations and is preceded by the exposure to several risk factors. Epidemiology has demonstrated that PDAC risk factors may be non-modifiable risks (sex, age, presence of genetic mutations, ethnicity) and modifiable and co-morbidity factors related to the specific habits and lifestyle. Recently it has become evident that obesity and diabetes are two important modifiable risk factors for PDAC. Obesity and diabetes are complex systemic and intertwined diseases and, over the years, experimental evidence indicate that insulin-resistance, alteration of adipokines, especially l

SUBMITTER: Polvani S 

PROVIDER: S-EPMC4768191 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature