Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.

ABSTRACT:

Background

Breast cancer (BC) is the most prevalent cancer in women and a major public health problem in Morocco. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. Therefore, we investigated the potential association of several functional germline variants in the genes commonly mutated in sporadic breast cancer.

Methods

In this case-control study, we examined 36 single nucleotide polymorphisms (SNPs) in 13 genes (APOBEC3A, APOBEC3B, ARID1B, ATR, MAP3K1, MLL2, MLL3, NCOR1, RUNX1, SF3B1, SMAD4, TBX3, TTN), which were located in the core promoter, 5'-and 3'UTR or which were nonsynonymous SNPs to assess their potential association with inherited predisposition to breast cancer development. Additio

SUBMITTER: Marouf C 

PROVIDER: S-EPMC4768349 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature