Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation.

ABSTRACT:

Background

Conditions of inflammatory tissue distress are associated with high extracellular levels of adenosine, due to increased adenosine triphosphate (ATP) degradation upon cellular stress or the release of extracellular ATP upon cell death, which can be degraded to adenosine by membrane-bound ecto-enzymes like CD39 and CD73. Adenosine is recognised to mediate anti-inflammatory effects via the adenosine A2a receptor (A2aR), as shown in experimental models of arthritis. Here, using pharmacological interventions and genetic inactivation, we investigated the roles of A2aR in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).

Methods

We used two independent mouse EAE variants, i.e. active immunization in C57BL/6 with myelin oligodend

SUBMITTER: Ingwersen J 

PROVIDER: S-EPMC4768407 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature