Structural modeling of the flagellum MS ring protein FliF reveals similarities to the type III secretion system and sporulation complex.

ABSTRACT: The flagellum is a large proteinaceous organelle found at the surface of many bacteria, whose primary role is to allow motility through the rotation of a long extracellular filament. It is an essential virulence factor in many pathogenic species, and is also a priming component in the formation of antibiotic-resistant biofilms. The flagellum consists of the export apparatus on the cytosolic side; the basal body and rotor, spanning the bacterial membrane(s) and periplasm; and the hook-filament, that protrudes away from the bacterial surface. Formation of the basal body MS ring region, constituted of multiple copies of the protein FliF, is one of the initial steps of flagellum assembly. However, the precise architecture of FliF is poorly understood. Here, I report a bioinformatics analysis o

SUBMITTER: Bergeron JR 

PROVIDER: S-EPMC4768692 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature