Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.

ABSTRACT: Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic response and tissue damage. As initial experiments showed that treatment with a calcium chelator after spinal cord injury reduced apoptosis and cavitation, we hypothesized that developmentally regulated mediators of calcium-dependent processes in secondary injury response may contribute to loss of regenerative ability. To this purpose we screened for such changes in chick spinal cords at stages of development permissive (E11) and non-permissive (E15) for regeneration. Among the developmentally regulated calcium-dependent proteins identified was PA

SUBMITTER: Lange S 

PROVIDER: S-EPMC4768803 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature