Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection.

ABSTRACT:

Background

It is unclear whether therapy for human immunodeficiency virus type 1 (HIV-1) should be initiated with a four-drug or two sequential three-drug regimens.

Methods

In this multicenter trial we compared initial therapy involving four-drug regimens containing efavirenz and nelfinavir in combination with either didanosine and stavudine or zidovudine and lamivudine with therapy involving two consecutive three-drug regimens the first of which contained either efavirenz or nelfinavir.

Results

A total of 980 subjects were followed for a median of 2.3 years. There was no significant difference in the occurrence of regimen failures between the group that received the four-drug regimen containing didanosine, stavudine, nelfinavir, and efavirenz and the groups that rece

SUBMITTER: Shafer RW 

PROVIDER: S-EPMC4768873 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature