Integrative Biology of Diabetic Kidney Disease.

ABSTRACT:

Background

The leading cause of ESRD in the U.S. is diabetic kidney disease (DKD). Despite significant efforts to improve outcomes in DKD, the impact on disease progression has been disappointing. This has prompted clinicians and researchers to search for alternative approaches to identify persons at risk, and to search for more effective therapies to halt progression of DKD. Identification of novel therapies is critically dependent on a more comprehensive understanding of the pathophysiology of DKD, specifically at the molecular level. A more expansive and exploratory view of DKD is needed to complement more traditional research approaches that have focused on single molecules.

Summary

In recent years, sophisticated research methodologies have emerged within systems biology

SUBMITTER: Harder JL 

PROVIDER: S-EPMC4768943 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature