Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer.

ABSTRACT: The present study aimed to investigate the molecular mechanisms underlying non‑syndromic cleft lip, with or without cleft palate (NSCL/P), and the association between this disease and cancer. The GSE42589 data set was downloaded from the Gene Expression Omnibus database, and contained seven dental pulp stem cell samples from children with NSCL/P in the exfoliation period, and six controls. Differentially expressed genes (DEGs) were screened using the RankProd method, and their potential functions were revealed by pathway enrichment analysis and construction of a pathway interaction network. Subsequently, cancer genes were obtained from six cancer databases, and the cancer‑associated protein‑protein interaction network for the DEGs was visualized using Cytoscape. In total, 452 upregulated a

SUBMITTER: Wang H 

PROVIDER: S-EPMC4768957 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature