Dose Escalation and Healthcare Resource Use among Ulcerative Colitis Patients Treated with Adalimumab in English Hospitals: An Analysis of Real-World Data.

ABSTRACT:

Objective

To describe the real-world use of adalimumab for maintenance treatment of ulcerative colitis (UC) and associated healthcare costs in English hospitals.

Design

Retrospective cohort study.

Setting

Analysis of NHS Hospital Episode Statistics linked with pharmacy dispensing data in English hospitals.

Patients

Adult UC patients receiving ≥240mg during adalimumab treatment induction, subsequently maintained on adalimumab.

Outcomes

Frequency and pattern of adalimumab use and dose escalation during maintenance treatment and associated healthcare costs (prescriptions and hospital visits).

Results

191 UC patients completed adalimumab treatment induction. 83 (43.46%) dose escalated during maintenance treatment by ≥100% (equivalent to weekly dosing)

SUBMITTER: Black CM 

PROVIDER: S-EPMC4768958 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature