Repeatability of (31) P MRSI in the human brain at 7 T with and without the nuclear Overhauser effect.

ABSTRACT: An often-employed strategy to enhance signals in (31) P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the (31) P data, because variation is reported in NOE enhancements. This would negate the signal-to-noise (SNR) gain it generates. We hypothesized that the variation in NOE enhancement values is not caused by the variability in NOE itself, but is attributable to measurement uncertainties in the values used to calculate the enhancement. If true, the expected increase in SNR with NOE would improve the repeatability of (31) P MRS measurements. To verify this hypothesis, a repeatability study of native and NOE-enhanced (31) P MRSI was performed in the brains of seven healthy volunteers at 7

SUBMITTER: Lagemaat MW 

PROVIDER: S-EPMC4769102 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature