In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

ABSTRACT:

Purpose

To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models.

Materials and methods

Uncoated iron oxide particles 50-100 nm and 1-5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid-coated iron oxide beads were likewise tested in a serum flow chamber model without a magnet (ie, control) and with the small prototype magnet.

Results

Particles were successfully captured from solution. Particle concentrations in solution decreased in all experiments (P < .05 vs matched control runs). At 10 minutes, concentrations were 98% (50-100-nm particles in water with a

SUBMITTER: Mabray MC 

PROVIDER: S-EPMC4769113 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature