Device Closure of Patent Foramen Ovale After Stroke: Pooled Analysis of Completed Randomized Trials.

ABSTRACT:

Background

The comparative effectiveness of percutaneous closure of patent foramen ovale (PFO) plus medical therapy versus medical therapy alone for cryptogenic stroke is uncertain.

Objectives

The authors performed the first pooled analysis of individual participant data from completed randomized trials comparing PFO closure versus medical therapy in patients with cryptogenic stroke.

Methods

The analysis included data on 2 devices (STARFlex [umbrella occluder] [NMT Medical, Inc., Boston, Massachusetts] and Amplatzer PFO Occluder [disc occluder] [AGA Medical/St. Jude Medical, St. Paul, Minnesota]) evaluated in 3 trials. The primary composite outcome was stroke, transient ischemic attack, or death; the secondary outcome was stroke. We used log-rank tests and unadjusted

SUBMITTER: Kent DM 

PROVIDER: S-EPMC4769377 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature