Prospective study of γ' fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE).

ABSTRACT:

Introduction

Epidemiological studies generally have not found plasma total fibrinogen to be a risk factor for venous thromboembolism (VTE), but several have reported associations between variants in the fibrinogen gamma gene (FGG) and VTE. A case-control study in whites suggested plasma γ' fibrinogen concentration may be associated inversely with VTE, but this was not replicated in African Americans.

Objective

To examine the prospective association between γ' fibrinogen concentrations and occurrence of VTE.

Methods

We used the Longitudinal Investigation of Thromboembolism Etiology (LITE), involving two pooled population-based cohorts in the United States including 16,234 participants. The cohorts comprised white and African American men and women, aged 50years and old

SUBMITTER: Folsom AR 

PROVIDER: S-EPMC4769380 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature