Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.

ABSTRACT:

Background

Previous studies of vitamin C and kidney stones were conducted mostly in men and either reported disparate results for supplemental and dietary vitamin C or did not examine dietary vitamin C.

Study design

Prospective cohort analysis.

Setting & participants

156,735 women in the Nurses' Health Study (NHS) I and II and 40,536 men in the Health Professionals Follow-up Study (HPFS).

Predictor

Total, dietary, and supplemental vitamin C intake, adjusted for age, body mass index, thiazide use, and dietary factors.

Outcomes

Incident kidney stones.

Results

During a median follow-up of 11.3 to 11.7 years, 6,245 incident kidney stones were identified. After multivariable adjustment, total vitamin C intake (<90 [reference], 90-249, 250-499, 500-999,

SUBMITTER: Ferraro PM 

PROVIDER: S-EPMC4769668 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature