Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice.

ABSTRACT:

Objective

Roux-en-Y gastric bypass surgery (RYGB) results in sustained lowering of body weight in most patients, but the mechanisms involved are poorly understood. The aim of this study was to obtain support for the notion that reprogramming of defended body weight, rather than passive restriction of energy intake, is a fundamental mechanism of RYGB.

Methods

Male C57BL6J mice reaching different degrees of obesity on a high-fat diet either with ad libitum access or with caloric restriction (weight-reduced) were subjected to RYGB.

Results

RYGB-induced weight loss and fat mass loss were proportional to pre-surgical levels, with moderately obese mice losing less body weight and fat compared with very obese mice. Remarkably, mice that were weight-reduced to the level of ch

SUBMITTER: Hao Z 

PROVIDER: S-EPMC4769678 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature