Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.

ABSTRACT:

Background

The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

Results

This study characterizes the structures of the soluble domains of two conserved core ESX-1 components - EccB1 and EccD1. The periplasmic domain of EccB1 consists of 4 repeat domains and a central domain, which together form a quasi 2-fold symmetrical structure. The repeat domains of EccB1 are structurally similar to a known peptidoglycan binding protein suggest

SUBMITTER: Wagner JM 

PROVIDER: S-EPMC4769845 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature