Paternal heat exposure causes DNA methylation and gene expression changes of Stat3 in Wild guinea pig sons.

ABSTRACT: Epigenetic mechanisms convey environmental information through generations and can regulate gene expression. Epigenetic studies in wild mammals are rare, but enable understanding adaptation processes as they may occur in nature. In most wild mammal species, males are the dispersing sex and thus often have to cope with differing habitats and thermal changes more rapidly than the often philopatric females. As temperature is a major environmental selection factor, we investigated whether genetically heterogeneous Wild guinea pig (Cavia aperea) males adapt epigenetically to an increase in temperature, whether that response will be transmitted to the next generation(s), and whether it regulates mRNA expression. Five (F0) adult male guinea pigs were exposed to an increased ambient temperature fo

SUBMITTER: Weyrich A 

PROVIDER: S-EPMC4769883 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature