Azithromycin use and outcomes in severe sepsis patients with and without pneumonia.

ABSTRACT:

Purpose

Studies investigating the association between macrolides and outcomes in both pulmonary and nonpulmonary critically ill patients are limited. We aimed to examine the association between azithromycin use and clinical outcomes in severe sepsis patients with and without pneumonia receiving mechanical ventilation.

Materials and methods

A retrospective cohort of 105 patients admitted to an adult intensive care unit (ICU) with severe sepsis in an urban university hospital were included in the study. Multivariable linear regression was performed to assess the relationship between azithromycin use and the following outcomes: 28-day ICU-free days and 28-day ventilator-free days.

Results

In univariate analysis, patients receiving azithromycin had nearly 6 more ICU-free

SUBMITTER: Afshar M 

PROVIDER: S-EPMC4769933 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature