Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health.

ABSTRACT:

Background

While additional research is needed, a number of large epidemiological studies show an association between circadian disruption and metabolic disorders. Specifically, obesity, insulin resistance, cardiovascular disease, and other signs of metabolic syndrome all have been linked to circadian disruption in humans. Studies in other species support this association and generally reveal that feeding that is not in phase with the external light/dark cycle, as often occurs with night or rotating shift workers, is disadvantageous in terms of energy balance. As food is a strong driver of circadian rhythms in the periphery, understanding how nutrient metabolism drives clocks across the body is important for dissecting out why circadian misalignment may produce such metabolic effec

SUBMITTER: Ribas-Latre A 

PROVIDER: S-EPMC4770266 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature