Functional elucidation of the non-coding RNAs of Kluyveromyces marxianus in the exponential growth phase.

ABSTRACT:

Background

Non-coding RNAs (ncRNAs), which perform diverse regulatory roles, have been found in organisms from all superkingdoms of life. However, there have been limited numbers of studies on the functions of ncRNAs, especially in nonmodel organisms such as Kluyveromyces marxianus that is widely used in the field of industrial biotechnology.

Results

In this study, we measured changes in transcriptome at three time points during the exponential growth phase of K. marxianus by using strand-specific RNA-seq. We found that approximately 60% of the transcriptome consists of ncRNAs transcribed from antisense and intergenic regions of the genome that were transcribed at lower levels than mRNA. In the transcriptome, a substantial number of long antisense ncRNAs (lancRNAs) are diffe

SUBMITTER: Cho YB 

PROVIDER: S-EPMC4770515 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature