Analysis of the redox oscillations in the circadian clockwork.

ABSTRACT: The evolution of tight coupling between the circadian system and redox homeostasis of the cell has been proposed to coincide roughly with the appearance of the first aerobic organisms, around 3 billion years ago. The rhythmic production of oxygen and its effect on core metabolism are thought to have exerted selective pressure for the temporal segregation of numerous metabolic pathways. Until recently, the only evidence for such coupling came from studies showing circadian cycles in the abundance of various redox metabolites, with many arguing that these oscillations are simply an output from the transcription-translation feedback loop. The recent discovery that the peroxiredoxin (PRX) proteins exhibit circadian cycles in their oxidation status, even in the absence of transcription, demonst

SUBMITTER: Milev NB 

PROVIDER: S-EPMC4770518 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature