Vimentin and Ki67 expression in circulating tumour cells derived from castrate-resistant prostate cancer.

ABSTRACT:

Background

High circulating tumor cell (CTC) counts are associated with poor prognosis in advanced prostate cancer, and recently CTC number was suggested to be a surrogate for survival in metastatic castrate-resistant prostate cancer (mCRPC). Ki67 and vimentin are well-characterised markers of tumour cell proliferation and the epithelial-mesenchymal transition (EMT), respectively. Here we asked if the expression of vimentin and Ki67 in CTCs offered prognostic or predictive information in mCRPC.

Methods

In two separate patient cohorts, anti-vimentin or anti-Ki67 antibodies were added to the free channel in the CellSearch® system for analysis of peripheral blood samples. For each cohort, association of CTC number with clinical characteristics were assessed using Fisher's exact

SUBMITTER: Lindsay CR 

PROVIDER: S-EPMC4770547 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature