Mining continuous intracranial EEG in focal canine epilepsy: Relating interictal bursts to seizure onsets.

ABSTRACT:

Objective

Brain regions are localized for resection during epilepsy surgery based on rare seizures observed during a short period of intracranial electroencephalography (iEEG) monitoring. Interictal epileptiform bursts, which are more prevalent than seizures, may provide complementary information to aid in epilepsy evaluation. In this study, we leverage a long-term iEEG dataset from canines with naturally occurring epilepsy to investigate interictal bursts and their electrographic relationship to seizures.

Methods

Four dogs were included in this study, each monitored previously with continuous iEEG for periods of 475.7, 329.9, 45.8, and 451.8 days, respectively, for a total of >11,000 h. Seizures and bursts were detected and validated by two board-certified epileptologists.

SUBMITTER: Davis KA 

PROVIDER: S-EPMC4770560 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature