Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.

ABSTRACT: Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here we generate genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female meioses. Genotyping >4 million informative SNPs from 23 complete meioses allowed us to map 2,032 maternal and 1,342 paternal crossovers and to infer the segregation patterns of 529 chromosome pairs. We uncover a new reverse chromosome segregation pattern in which both homologs separate their sister chromatids at meiosis I; detect selection for higher recombination rates in the female germ line by the elimination of aneuploid embryos; and report chromosoma

SUBMITTER: Ottolini CS 

PROVIDER: S-EPMC4770575 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature