Antagonism between Staphylococcus epidermidis and Propionibacterium acnes and its genomic basis.

ABSTRACT:

Background

Propionibacterium acnes and Staphylococcus epidermidis live in close proximity on human skin, and both bacterial species can be isolated from normal and acne vulgaris-affected skin sites. The antagonistic interactions between the two species are poorly understood, as well as the potential significance of bacterial interferences for the skin microbiota. Here, we performed simultaneous antagonism assays to detect inhibitory activities between multiple isolates of the two species. Selected strains were sequenced to identify the genomic basis of their antimicrobial phenotypes.

Results

First, we screened 77 P. acnes strains isolated from healthy and acne-affected skin, and representing all known phylogenetic clades (I, II, and III), for their antimicrobial activities a

SUBMITTER: Christensen GJ 

PROVIDER: S-EPMC4770681 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature