An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype.

ABSTRACT: Although clinical features, cytogenetics, and mutations are widely used to predict prognosis in patients with acute myeloid leukemia (AML), further refinement of risk stratification is necessary for optimal treatment, especially in cytogenetically normal (CN) patients. We sought to generate a simple gene expression signature as a predictor of clinical outcome through analyzing the mRNA arrays of 158 de novo CN AML patients. We compared the gene expression profiles of patients with poor response to induction chemotherapy with those who responded well. Forty-six genes expressed differentially between the two groups. Among them, expression of 11 genes was significantly associated with overall survival (OS) in univariate Cox regression analysis in 104 patients who received standard intensive c

SUBMITTER: Chuang MK 

PROVIDER: S-EPMC4770759 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature