Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study.

ABSTRACT:

Objective

To evaluate if oral fluoroquinolone use is associated with an increased risk of serious arrhythmia.

Design

Bi-national cohort study, linking register data on filled prescriptions, cases of serious arrhythmia, and patient characteristics.

Setting

Denmark, 1997-2011; Sweden, 2006-13.

Participants

The study cohort was derived from a source population of all Danish and Swedish adults, aged 40 to 79 years. 909,656 courses of fluoroquinolone use (ciprofloxacin 82.6%, norfloxacin 12.1%, ofloxacin 3.2%, moxifloxacin 1.2%, and other fluoroquinolones 0.9%) and 909,656 courses of penicillin V use, matched 1:1 on propensity score, were included.

Main outcome measure

The main outcome was risk of serious arrhythmia (fatal and non-fatal), comparing courses of

SUBMITTER: Inghammar M 

PROVIDER: S-EPMC4770814 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature