Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses.

ABSTRACT:

Objective

To assess the effect of antihypertensive treatment on mortality and cardiovascular morbidity in people with diabetes mellitus, at different blood pressure levels.

Design

Systematic review and meta-analyses of randomised controlled trials.

Data sources

CENTRAL, Medline, Embase, and BIOSIS were searched using highly sensitive search strategies. When data required according to the protocol were missing but trials were potentially eligible, we contacted researchers, pharmaceutical companies, and authorities.

Eligibility criteria

Randomised controlled trials including 100 or more people with diabetes mellitus, treated for 12 months or more, comparing any antihypertensive agent against placebo, two agents against one, or different blood pressure targets.

SUBMITTER: Brunstrom M 

PROVIDER: S-EPMC4770818 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature