Ontology highlight
ABSTRACT:
SUBMITTER: Andrews SF
PROVIDER: S-EPMC4770855 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Science translational medicine 20151201 316
Generating a broadly protective influenza vaccine is critical to global health. Understanding how immune memory influences influenza immunity is central to this goal. We undertook an in-depth study of the B cell response to the pandemic 2009 H1N1 vaccine over consecutive years. Analysis of monoclonal antibodies generated from vaccine-induced plasmablasts demonstrated that individuals with low preexisting serological titers to the vaccinating strain generated a broadly reactive, hemagglutinin (HA ...[more]