Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort.

ABSTRACT:

Introduction

The disease spectrum for HIV-infected individuals has shifted toward comorbid non-AIDS conditions including chronic lung disease, but quantitative image analysis of lung disease has not been performed.

Objectives

To quantify the prevalence of structural changes of the lung indicating emphysema or fibrosis on radiographic examination.

Methods

A cross-sectional analysis of 510 HIV-infected participants in the multicenter Lung-HIV study was performed. Data collected included demographics, biological markers of HIV, pulmonary function testing, and chest computed tomographic examinations. Emphysema and fibrosis-like changes were quantified on computed tomographic images based on threshold approaches.

Results

In our cohort, 69% was on antiretroviral ther

SUBMITTER: Leader JK 

PROVIDER: S-EPMC4770858 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature