MicroCT-based virtual histology evaluation of preclinical medulloblastoma.

ABSTRACT:

Purpose

The purpose of this paper is to validate a rapid and cost-effective ex vivo technique, microCT-based virtual histology, as an alternative to MRI imaging for assessing the therapeutic response in genetically engineered mouse models of cancer.

Procedures

All animal procedures were conducted in accordance with the Guidelines for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Texas Health Science Center at San Antonio. MRI imaging was performed on 6-week-old, bortezomib-treated genetically engineered Patched1, p53 mice that recapitulate the characteristics of human medulloblastoma. After MRI scans, the same mice were euthanized to collect brain or spine samples for virtual histology

SUBMITTER: Prajapati SI 

PROVIDER: S-EPMC4770897 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature