Blood Transcriptomic Markers in Patients with Late-Onset Major Depressive Disorder.

ABSTRACT: We investigated transcriptomic markers of late-onset major depressive disorder (LOD; onset age of first depressive episode ≥ 50 years) from the genes expressed in blood cells and identified state-dependent transcriptomic markers in these patients. We assessed the genes expressed in blood cells by microarray and found that the expression levels of 3,066 probes were state-dependently changed in the blood cells of patients with LOD. To select potential candidates from those probes, we assessed the genes expressed in the blood of an animal model of depression, ovariectomized female mice exposed to chronic ultra-mild stress, by microarray and cross-matched the differentially expressed genes between the patients and the model mice. We identified 14 differentially expressed genes that were simila

SUBMITTER: Miyata S 

PROVIDER: S-EPMC4771207 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature