A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes.

ABSTRACT: For medical biologists, sequencing has become a commonplace technique to support diagnosis. Rapid changes in this field have led to the generation of large amounts of data, which are not always correctly listed in databases. This is particularly true for data concerning class A β-lactamases, a group of key antibiotic resistance enzymes produced by bacteria. Many genomes have been reported to contain putative β-lactamase genes, which can be compared with representative types. We analyzed several hundred amino acid sequences of class A β-lactamase enzymes for phylogenic relationships, the presence of specific residues, and cluster patterns. A clear distinction was first made between dd-peptidases and class A enzymes based on a small number of residues (S70, K73, P107, 130SDN132, G144, E166,

SUBMITTER: Philippon A 

PROVIDER: S-EPMC4771212 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature