Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization.

ABSTRACT: The steroid hormones 17β-estradiol and progesterone are critical regulators of endometrial stromal cell differentiation, known as decidualization, which is a prerequisite for successful establishment of pregnancy. The present study using primary human endometrial stromal cells (HESCs) addressed the role of estrogen receptor-α (ESR1) in decidualization. Knockdown of ESR1 transcripts by RNA interference led to a marked reduction in decidualization of HESCs. Gene expression profiling at an early stage of decidualization indicated that ESR1 negatively regulates several cell cycle regulatory factors, thereby suppressing the proliferation of HESCs as these cells enter the differentiation program. ESR1 also controls the expression of WNT4, FOXO1, and progesterone receptor (PGR), well-known mediat

SUBMITTER: Kaya Okur HS 

PROVIDER: S-EPMC4771698 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature