ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones.

ABSTRACT: Total mass of mitochondria increases during cell proliferation and differentiation through mitochondrial biogenesis, which includes mitochondrial proliferation and growth. During the mitochondrial growth, individual mitochondria have been considered to be enlarged independently of mitochondrial fusion. However, molecular basis for this enlarging process has been poorly understood. Cone photoreceptor cells in the retina possess large mitochondria, so-called mega-mitochondria that have been considered to arise via the enlarging process. Here we show that ES1 is a novel mitochondria-enlarging factor contributing to form mega-mitochondria in cones. ES1 is specifically expressed in cones and localized to mitochondria including mega-mitochondria. Knockdown of ES1 markedly reduced the mitochondri

SUBMITTER: Masuda T 

PROVIDER: S-EPMC4772128 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature