Ontology highlight
ABSTRACT:
SUBMITTER: Ferenczi EA
PROVIDER: S-EPMC4772156 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160101 6268
Motivation for reward drives adaptive behaviors, whereas impairment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, including depression and schizophrenia. We sought to test the hypothesis that the medial prefrontal cortex (mPFC) controls interactions among specific subcortical regions that govern hedonic responses. By using optogenetic functional magnetic resonance imaging to locally manipulate but globally visualize neural activity in rats, we found that ...[more]