Dataset Information

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China.

ABSTRACT:

Objective

To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels.

Methods

A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313.

Results

(1) The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05); (2) the level of HDL-C (rs2515602 and rs2275542) in normal HDL-C subjects were different among the genotypes (p < 0.05); the levels of TC, LDL-C (rs2515602, rs4149313); TG (rs2515602, rs1800976, rs4149313) in low HDL-C patients were different among the genotypes (p < 0.05); (3) interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4) the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05).

Conclusions

The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.

SUBMITTER: Yao MH

PROVIDER: S-EPMC4772196 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Publications

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China.

Yao Ming-hong MH Guo Heng H He Jia J Yan Yi-zhong YZ Ma Ru-lin RL Ding Yu-song YS Zhang Jing-yu JY Liu Jia-ming JM Zhang Mei M Li Shu-gang SG Xu Shang-zhi SZ Niu Qiang Q Ma Jiao-long JL Guo Shu-xia SX

International journal of environmental research and public health 20160128 2

<h4>Objective</h4>To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels.<h4>Methods</h4>A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313.<h4>Results</h4>(1) The genotypic and allelic frequencies of rs ...[more]

PMID: 26828509

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Project description:BackgroundThe prevalence of diabetes and obesity has been continuously rising worldwide over the last three decades, particularly in China. The prevalence varies widely among different ethnicities. In this study, we investigated the prevalence of diabetes and obesity, as well as the associated factors for diabetes in Kazakh adults in Xinjiang to improve diabetes screening.MethodsWe collected data from the Xinjiang physical examination in 2018, including a total sample of 118,505 Kazakh adults in Altay District. Data on demographic characteristics, medical history, physical examination, fasting plasma glucose (FPG) and serum lipid profiles were collected. The chi-square test was used to examine the differences between multiple variables. Multivariate logistic regression was performed to identify the factors associated with diabetes.ResultsThe mean age was 43. 66 years (SD 14.14). 49.3% of the population were women and 75.5% were rural residents. The mean FPG was 5.33 mmol/L (SD 1.22). The prevalence of diabetes was 6.3% and 4.1% received a new diagnosis by FPG. 26.6% were diagnosed with impaired fasting glucose (IFG). The mean body mass index (BMI) was 26.29 kg/m2 (SD 14.14) and the mean waist circumference was 87.69 cm (SD 12.74). 33.2% of the population were overweight, and 33.0% were obese. The prevalence of central obesity was 51.4%. Diabetes was mostly positively associated with hypertension (OR = 3.821, P<0.001), hypertriglyceridemia (OR = 2.757, P<0.001), and hyper-LDL-cholesterolemia (OR = 2.331, P<0.001) in the Kazakh population. The ORs for overweight, obesity and central obesity predictive of diabetes were 1.265, 1.453 and 1.222 ( all P<0.001), respectively.ConclusionsDespite having a high prevalence of obesity and central obesity, the Kazakh population had a considerably low prevalence of diabetes. Obesity was not the most important risk factor for diabetes in Kazakh individuals. The awareness of diabetes was low. When screening for diabetes in Kazakhs, those with hypertension or dyslipidemia should receive more attention.

Project description:Migration processes, which intensified in the late twentieth and early twenty-first centuries, occur within a context of constant challenges and changing realities, necessitating new research in this area. Nearly all migrants, adapting to new forms of everyday existence, might experience socio-psychological stress. This study focuses on the socio-cultural and linguistic adaptation of the young generation of ethnic Kazakhs, as well as their psychological state within the educational environment, grounded in the concept of transnationalism. The authors conducted a survey and interviews with repatriate students from China and Mongolia in their native language, Kazakh. The research methodology, survey methodology and applied tools are comparable in terms of both qualitative and quantitative analysis. The sample population consisted of 230 respondents from five regions, aged between 16 and 25 years old. Furthermore, 30 qualitative, focused interviews were conducted. The discussion questions are related to several important factors, including the impact of the presence of relatives in the country of origin, the establishment of ties with them, and the integration of individuals into the social spheres of their historical homeland during their stay in Kazakhstan, as well as the processes of adaptation and integration into the new society. The results demonstrate the existence of transnational practices among the informants, which permits the categorization of these individuals as transnational migrants, despite the fact that a considerable number of them have completed the migration process. The findings of the research also indicated that repatriate students from Mongolia showed greater ease of adaptation in Kazakhstan, largely due to their more active communication with relatives and stronger inclination toward integration into local society. Conversely, Kazakh ethnic students from China, despite using contemporary communication technologies, encountered more challenges, largely due to emotional difficulties associated with the lack of physical proximity to their families and a prevalent intention to return to their families after graduation.

Dataset Information

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China.

Objective

Methods

Results

Conclusions

Publications

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China.

Similar Datasets

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