Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels.

ABSTRACT: We combined Hodgkin-Huxley equations and gating models of gap junction (GJ) channels to simulate the spread of excitation in two-dimensional networks composed of neurons interconnected by voltage-gated GJs. Each GJ channel contains two fast and slow gates, each exhibiting current-voltage (I-V) rectification and gating properties that depend on transjunctional voltage (Vj). The data obtained show how junctional conductance (gj), which is necessary for synchronization of the neuronal network, depends on its size and the intrinsic firing rate of neurons. A phase shift between action potentials (APs) of neighboring neurons creates bipolar, short-lasting Vj spikes of approximately ± 100 mV that induce Vj gating, leading to a small decay of gj, which can accumulate into larger decays during burs

SUBMITTER: Maciunas K 

PROVIDER: S-EPMC4772373 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature