Multicopy gene family evolution on primate Y chromosomes.

ABSTRACT:

Background

The primate Y chromosome is distinguished by a lack of inter-chromosomal recombination along most of its length, extensive gene loss, and a prevalence of repetitive elements. A group of genes on the male-specific portion of the Y chromosome known as the "ampliconic genes" are present in multiple copies that are sometimes part of palindromes, and that undergo a form of intra-chromosomal recombination called gene conversion, wherein the nucleotides of one copy are homogenized by those of another. With the aim of further understanding gene family evolution of these genes, we collected nucleotide sequence and gene copy number information for several species of papionin monkey. We then tested for evidence of gene conversion, and developed a novel statistical framework to eval

SUBMITTER: Ghenu AH 

PROVIDER: S-EPMC4772468 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature