Ontology highlight
ABSTRACT:
SUBMITTER: Karthaus WR
PROVIDER: S-EPMC4772677 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell 20140904 1
The prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murine lineage-tracing experiments show that luminal cells generate basal cells. It has remained challenging to address the molecular details of these transitions and whether they apply to humans, due to the lack of culture conditions that recapitulate prostate gland architecture. Here, we describe a 3D cultur ...[more]