Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study.

ABSTRACT:

Objective

To determine whether the use of incretin based drugs compared with sulfonylureas is associated with an increased risk of incident pancreatic cancer in people with type 2 diabetes.

Design

Population based cohort.

Setting

Large, international, multicentre study combining the health records from six participating sites in Canada, the United States, and the United Kingdom.

Participants

A cohort of 972,384 patients initiating antidiabetic drugs between 1 January 2007 and 30 June 2013, with follow-up until 30 June 2014.

Main outcome measures

Within each cohort we conducted nested case-control analyses, where incident cases of pancreatic cancer were matched with up to 20 controls on sex, age, cohort entry date, duration of treated diabetes, and durati

SUBMITTER: Azoulay L 

PROVIDER: S-EPMC4772785 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature