Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study.

ABSTRACT:

Objectives

To investigate the risks of invasive cervical cancer after detection of atypical glandular cells (AGC) during cervical screening.

Design

Nationwide population based cohort study.

Setting

Cancer and population registries in Sweden.

Participants

3,054,328 women living in Sweden at any time between 1 January 1980 and 1 July 2011 who had any record of cervical cytological testing at ages 23-59. Of these, 2,899,968 women had normal cytology results at the first screening record. The first recorded abnormal result was atypical glandular cells (AGC) in 14 625, high grade squamous intraepithelial lesion (HSIL) in 65 633, and low grade squamous intraepithelial lesions (LSIL) in 244 168.

Main outcome measures

Cumulative incidence of invasive cervical ca

SUBMITTER: Wang J 

PROVIDER: S-EPMC4772788 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature