Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling.

ABSTRACT:

Rationale

Adiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium.

Objective

To explore the cross talk between EpAT-derived adiponectin and myocardial redox state in the human heart.

Methods and results

EpAT and atrial myocardium were obtained from 306 patients undergoing coronary artery bypass grafting. Functional genetic polymorphisms that increase ADIPOQ expression (encoding adiponectin) led to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O2 (-), whereas circulating adiponectin and ADIPOQ expressi

SUBMITTER: Antonopoulos AS 

PROVIDER: S-EPMC4772814 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature