Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System.

ABSTRACT: The inner ear vestibular system has numerous projections on central brain centers that regulate sympathetic outflow, and skeletal sympathetic projections affect bone remodeling by inhibiting bone formation by osteoblasts and promoting bone resorption by osteoclasts. In this study, we show that bilateral vestibular lesions in mice cause a low bone mass phenotype associated with decreased bone formation and increased bone resorption. This reduction in bone mass is most pronounced in lower limbs, is not associated with reduced locomotor activity or chronic inflammation, and could be prevented by the administration of the β-blocker propranolol and by genetic deletion of the β2-adrenergic receptor, globally or specifically in osteoblasts. These results provide novel experimental evidence suppor

SUBMITTER: Vignaux G 

PROVIDER: S-EPMC4772960 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature