Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment.

ABSTRACT:

Aim

To determine associations between methylation of NR3C1, HSD11B2, FKBP5 and ADCYAP1R1 and newborn neurobehavioral outcomes.

Methods

In 537 newborns, placental methylation was quantified using bisulfite pyrosequencing. Profiles of neurobehavior were derived via the Neonatal Intensive Care Unit Network Neurobehavioral Scales. Using exploratory factor analysis, the relationships between methylation factor scores and neurobehavioral profiles were examined.

Results

Increased scores of the factor characterized by NR3C1 methylation were associated with membership in a reactive, poorly regulated profile (odds ratio: 1.47; 95% CI: 1.00-2.18), while increased scores of the factor characterized by HSD11B2 methylation reduced this risk.

Conclusion

These results suggest

SUBMITTER: Paquette AG 

PROVIDER: S-EPMC4772971 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature