Safety of Levetiracetam in Paediatrics: A Systematic Review.

ABSTRACT:

Objective

To identify adverse events (AEs) associated with Levetiracetam (LEV) in children.

Methods

Databases EMBASE (1974-February 2015) and Medline (1946-February 2015) were searched for articles in which paediatric patients (≤18 years) received LEV treatment for epilepsy. All studies with reports on safety were included. Studies involving adults, mixed age population (i.e. children and adults) in which the paediatric subpopulation was not sufficiently described, were excluded. A meta-analysis of the RCTs was carried out and association between the commonly reported AEs or treatment discontinuation and the type of regimen (polytherapy or monotherapy) was determined using Chi2 analysis.

Results

Sixty seven articles involving 3,174 paediatric patients were identified.

SUBMITTER: Egunsola O 

PROVIDER: S-EPMC4773020 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature