ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer.

ABSTRACT: ADAM15 is a member of a family of catalytically active disintegrin membrane metalloproteinases that function as molecular signaling switches, shed membrane bound growth factors and/or cleave and inactivate cell adhesion molecules. Aberrant metalloproteinase function of ADAM15 may contribute to tumor progression through the release of growth factors or disruption of cell adhesion. In this study, we utilized human bladder cancer tissues and cell lines to evaluate the expression and function of ADAM15 in the progression of human bladder cancer. Examination of genome and transcriptome databases revealed that ADAM15 ranked in the top 5% of amplified genes and its mRNA was significantly overexpressed in invasive and metastatic bladder cancer compared to noninvasive disease. Immunostaining of a b

SUBMITTER: Lorenzatti Hiles G 

PROVIDER: S-EPMC4773041 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature