Characterization and Vaccine Potential of Outer Membrane Vesicles Produced by Haemophilus parasuis.

ABSTRACT: Haemophilus parasuis is a Gram-negative bacterium that colonizes the upper respiratory tract of swine and is capable of causing a systemic infection, resulting in high morbidity and mortality. H. parasuis isolates display a wide range of virulence and virulence factors are largely unknown. Commercial bacterins are often used to vaccinate swine against H. parasuis, though strain variability and lack of cross-reactivity can make this an ineffective means of protection. Outer membrane vesicles (OMV) are spherical structures naturally released from the membrane of bacteria and OMV are often enriched in toxins, signaling molecules and other bacterial components. Examination of OMV structures has led to identification of virulence factors in a number of bacteria and they have been successfully u

SUBMITTER: McCaig WD 

PROVIDER: S-EPMC4773134 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature