Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies.

ABSTRACT:

Objectives

Genome-wide association studies (GWASs) have revealed many SNPs and genes associated with osteoporosis. However, influence of these SNPs and genes on the predisposition to osteoporosis is not fully understood. We aimed to identify osteoporosis GWASs-associated SNPs potentially influencing the binding affinity of transcription factors and miRNAs, and reveal enrichment signaling pathway and "hub" genes of osteoporosis GWAS-associated genes.

Methods

We conducted multiple computational analyses to explore function and mechanisms of osteoporosis GWAS-associated SNPs and genes, including SNP conservation analysis and functional annotation (influence of SNPs on transcription factors and miRNA binding), gene ontology analysis, pathway analysis and protein-protein interact

SUBMITTER: Qin L 

PROVIDER: S-EPMC4773152 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature