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Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.

ABSTRACT:

SUBMITTER: Sissoko D 

PROVIDER: S-EPMC4773183 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.

Sissoko Daouda D   Laouenan Cedric C   Folkesson Elin E   M'Lebing Abdoul-Bing AB   Beavogui Abdoul-Habib AH   Baize Sylvain S   Camara Alseny-Modet AM   Maes Piet P   Shepherd Susan S   Danel Christine C   Carazo Sara S   Conde Mamoudou N MN   Gala Jean-Luc JL   Colin Géraldine G   Savini Hélène H   Bore Joseph Akoi JA   Le Marcis Frederic F   Koundouno Fara Raymond FR   Petitjean Frédéric F   Lamah Marie-Claire MC   Diederich Sandra S   Tounkara Alexis A   Poelart Geertrui G   Berbain Emmanuel E   Dindart Jean-Michel JM   Duraffour Sophie S   Lefevre Annabelle A   Leno Tamba T   Peyrouset Olivier O   Irenge Léonid L   Bangoura N'Famara N   Palich Romain R   Hinzmann Julia J   Kraus Annette A   Barry Thierno Sadou TS   Berette Sakoba S   Bongono André A   Camara Mohamed Seto MS   Chanfreau Munoz Valérie V   Doumbouya Lanciné L   Souley Harouna   Kighoma Patient Mumbere PM   Koundouno Fara Roger FR   Réné Lolamou   Loua Cécé Moriba CM   Massala Vincent V   Moumouni Kinda K   Provost Célia C   Samake Nenefing N   Sekou Conde C   Soumah Abdoulaye A   Arnould Isabelle I   Komano Michel Saa MS   Gustin Lina L   Berutto Carlotta C   Camara Diarra D   Camara Fodé Saydou FS   Colpaert Joliene J   Delamou Léontine L   Jansson Lena L   Kourouma Etienne E   Loua Maurice M   Malme Kristian K   Manfrin Emma E   Maomou André A   Milinouno Adele A   Ombelet Sien S   Sidiboun Aboubacar Youla AY   Verreckt Isabelle I   Yombouno Pauline P   Bocquin Anne A   Carbonnelle Caroline C   Carmoi Thierry T   Frange Pierre P   Mely Stéphane S   Nguyen Vinh-Kim VK   Pannetier Delphine D   Taburet Anne-Marie AM   Treluyer Jean-Marc JM   Kolie Jacques J   Moh Raoul R   Gonzalez Minerva Cervantes MC   Kuisma Eeva E   Liedigk Britta B   Ngabo Didier D   Rudolf Martin M   Thom Ruth R   Kerber Romy R   Gabriel Martin M   Di Caro Antonino A   Wölfel Roman R   Badir Jamal J   Bentahir Mostafa M   Deccache Yann Y   Dumont Catherine C   Durant Jean-François JF   El Bakkouri Karim K   Gasasira Uwamahoro Marie M   Smits Benjamin B   Toufik Nora N   Van Cauwenberghe Stéphane S   Ezzedine Khaled K   D'Ortenzio Eric E   Pizarro Louis L   Etienne Aurélie A   Guedj Jérémie J   Fizet Alexandra A   Barte de Sainte Fare Eric E   Murgue Bernadette B   Tran-Minh Tuan T   Rapp Christophe C   Piguet Pascal P   Poncin Marc M   Draguez Bertrand B   Allaford Duverger Thierry T   Barbe Solenne S   Baret Guillaume G   Defourny Isabelle I   Carroll Miles M   Raoul Hervé H   Augier Augustin A   Eholie Serge P SP   Yazdanpanah Yazdan Y   Levy-Marchal Claire C   Antierrens Annick A   Van Herp Michel M   Günther Stephan S   de Lamballerie Xavier X   Keïta Sakoba S   Mentre France F   Anglaret Xavier X   Malvy Denis D  

PLoS medicine 20160301 3

<h4>Background</h4>Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health Organization released a short list of drugs suitable for EVD research. Favipiravir, an antiviral developed for the treatment of severe influenza, was one of these. In late 2014, the conditions for starting a randomized Ebola trial were not fulfilled for two reasons. One was the perception that,  ...[more]

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